Innovation Saving Lives

We are a biotechnology company with a proprietary biomarker discovery platform, EpiSwitch™, based on the latest advances in gene expression,non-coding RNA and epigenetics.

Episwitch™ biomarkers based on chromosomal conformation signatures are a critical cog in personalised medicine.

Technology to select the right drug at the right dose at the right time for the right patient.

Recent Publications on Chromosome Conformation Signatures


Systematic analysis of chromatin interactions at disease associated loci links novel candidate genes to inflammatory bowel disease.

Meddens et. al.
Genome Biology
https://www.ncbi.nlm.nih.gov/pubmed/27903283

Identifying Causal Genes at the Multiple Sclerosis Associated Region 6q23 Using Capture Hi-C.

Martin et. al.
PLOS ONE
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0166923

Lineage-Specific Genome Architecture Links Enhancers and Non-coding Disease Variants to Target Gene Promoters.

Javierre et. al.
Cell
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5123897/

A Compendium of Chromatin Contact Maps Reveals Spatially Active Regions in the Human Genome.

Schmitt et. al.
Cell Reports
http://www.cell.com/cell-reports/abstract/S2211-1247(16)31481-4?_returnURL=http%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2211124716314814%3Fshowall%3Dtrue

The Genome Conformation As an Integrator of Multi-Omic Data: The Example of Damage Spreading in Cancer.

Tordini et. al.
Frontiers in Genetics
http://journal.frontiersin.org/article/10.3389/fgene.2016.00194/full