Formation of distinct chromatin conformation signatures epigenetically regulate macrophage activation.

A collaboration between Oxford BioDynamics and Professor Siamon Gordon (Oxford University), has utilised EpiSwitch™ technology for successful identification of regulatory chromosome conformation signatures as epigenetic biomarkers for innate, alternative and classical activation states in macrophages stimulated with LPS, IL-4 and IFN-γ. Available at: International Immunopharmacology 2014 Jan;18(1):7-11