Innovation Saving Lives

We are a biotechnology company with a proprietary epigenetic biomarker discovery platform, EpiSwitch™, based on the latest advances in regulatory genome architecture and its link to clinical outcomes and patient stratification.

EpiSwitch™ biomarkers based on chromosomal conformation signatures are a critical cog in personalised medicine.

Technology to select the right drug at the right dose at the right time for the right patient.

EpiSwitch™ captures the heterogeneity of the environment on the genome.

Our Publications on Episwitch™


Epigenetic Chromosome Conformations Predict MTX Responsiveness in Early Rheumatoid Arthritis Patients.

Carini, C., et. al.,
Annual Meeting of the American College of Rheumatology
http://acrabstracts.org/abstract/epigenetic-chromosome-conformations-predict-mtx-responsiveness-in-early-rheumatoid-arthritis-patients/

Development of Epigenetic Profiling of ALS Patients with Chromosome Conformation Biomarkers Offers Novel Signatures for Non-invasive Diagnostic and Prognostic Stratifications.

Hunter, E., et. al.,
14th Annual Northeast Amyotrophic Lateral Sclerosis Consortium
http://www.oxfordbiodynamics.com/wp-content/uploads/2016/10/ALSNEALS2015.pdf

A pilot study of chromosomal aberrations and epigenetic changes in peripheral blood samples to identify patients with melanoma.

Jakub, JW., et. al.,
Melanoma Research
https://www.ncbi.nlm.nih.gov/pubmed/26225582

Chromatin barcodes as biomarkers for melanoma.

Bastonini, E., et. al.,
Pigment Cell Melanoma Research
https://www.ncbi.nlm.nih.gov/pubmed/24807349

A blood-based epigenetic test for early detection of hepatocellular carcinoma (HCC).

Lim, EH., et. al.,
J Clinical Oncology
http://meetinglibrary.asco.org/content/133682-144

Chromatin signatures of DLBCL subtypes.

Field, et. al.,
Cancer Research
http://cancerres.aacrjournals.org/content/74/19_Supplement/462

Current Advances in Epigenetics.

Hunter, et., al.,
Clinical and Statistical Consideration in Personalized Medicine
http://www.oxfordbiodynamics.com/2014/03/27/current-advances-in-epigenetics/

Formation of distinct chromatin conformation signatures epigenetically regulate macrophage activation.

Mukhopadhyay, et. al.,
International Immunopharmacology
https://www.ncbi.nlm.nih.gov/pubmed/24211766

Validation of a new Epigenetic-based Prognostic Blood test to predict Prostate Cancer Aggressiveness

Pchejetski, D, et. al.,
Annals of Oncology
http://doi:10.1093/annonc/mdt459.36

Development of novel ALS treatment on the basis of mechanisms of cellular chronological life span control.

Youdell, M., et.al.,
12th Annual Northeast Amyotrophic Lateral Sclerosis Consortium
http://www.oxfordbiodynamics.com/wp-content/uploads/2016/10/ALS-POSTER.pdf