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EpiSwitch™

The packaging of chromosomal DNA plays a critical role in the epigenetic regulation of the whole genome. It ensures effective storage, access to genetic information and its regulation by the complex protein machinery utilised in gene expression. Known also as ‘gene loops’, ‘long-range chromosomal interactions’ and ‘chromatin domains’, CCSs have been recognised as an essential high-level framework of epigenetic regulation imposed across the whole genome and reflecting its fractal nature of organisation.

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  • Say goodbye to ”genome walking” with traditional 3C
  • With the pre-existing knowledge built into the EpiSwitch™ technology platform we already know where to look so there is no need to “walk” along the genome as in traditional 3C experiments.
  • Expanding this knowledge across the genome allows for the identification of the most likely chromosome conformations that may be biologically relevant for your model of interest.
  • With the EpiSwitch™ Microarrays you can simultaneously investigate over 960,000 high confidence chromosome conformations across the genome using the optimized EpiSwitch™ 3C protocol.
  • The predicted chromosomes conformations are phenotype/disease agnostic allowing for the same designs to be used across multiple experiments and research questions.

The EpiSwitch™ Microarray kits contain the EpiSwitch Buffer system and choice of two custom CGH Microarray designs  to interrogate the 3D genome of your own phenotype/model

Design One – Coding Centric Design (X-HS-AC-02)

Investigate the genome-wide 3D architecture located around both protein and lncRNA coding regions.

Design Two – Untargeted Design (X-HS-AB-02)

Investigate the 3D architecture across the whole genome with no bias towards known gene annotations, Array probe selection performed solely on EpiSwitch annotations

Don’t have access to CGH microarray services? Let us take the strain. The Microarray Kits are also offered as an in-house service. Ship your samples to our reference laboratory and our experienced technicians will perform the protocols for you, delivering high-quality results.

The new EpiSwitch™ Microarray kit puts the power of the EpiSwitch™ platform in your hands

EpiSwitch™ Advantage

Cut through the noise

  • Avoid genome walking and go directly to predicted high confidence chromosomes conformations for differential analysis in your phenotype/model of choice

Genome-wide scope

  • Avoid biasing your microarrays and analysis by using independent genome-wide EpiSwitch™ annotations that are phenotype/disease agnostic.

Quicker results

  • One day library preparation with the EpiSwitch™ library preparation kit
  • Only three days of array processing time – providing samples to results in as little as 4 days.

Easier analytics

  • Use the EpiSwitch™ analytical portals for easy, upfront analysis and contextual integrations. No coding or statistical knowledge required
  • Perform your own analysis and upload data to the EpiSwitch™ portal in standard formats

Interested in the EpiSwitch™ Microarray kit and service – sign up for Updates and release dates below.

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EpiSwitchTM Microarray Kits and services are for Research Use Only- Not for Use in Diagnostic Procedures. For our clinical biomarker development services click the image below

EpiSwitch™ Product Development Pipeline

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