Innovation Saving Lives

We are a biotechnology company with a proprietary biomarker discovery platform, EpiSwitch™, based on the latest advances in gene expression,non-coding RNA and epigenetics.

EpiSwitch™ biomarkers based on chromosomal conformation signatures are a critical cog in personalised medicine.

Technology to select the right drug at the right dose at the right time for the right patient.

EpiSwitch™ captures the heterogeneity of the environment on the genome.

Recent Publications on Chromosome Conformation Signatures


Epigenetic maintenance of topological domains in the highly rearranged gibbon genome.

Lazar NH, et. al.
Genome Res.
https://www.ncbi.nlm.nih.gov/pubmed/29914971

Transcription factors orchestrate dynamic interplay between genome topology and gene regulation during cell reprogramming.

Stadhouders R, et. al.
Nat Genet.
https://www.ncbi.nlm.nih.gov/pubmed/?term=Transcription+factors+orchestrate+dynamic+interplay+between+genome+topology+and+gene+regulation+during+cell+reprogramming

Stratification of TAD boundaries reveals preferential insulation of super-enhancers by strong boundaries.

Gong Y, et. al.
Nat Commun.
https://www.ncbi.nlm.nih.gov/pubmed/29416042

A maximum-entropy model for predicting chromatin contacts.

PLoS Comput Biol.
Farre P. et. al.
https://www.ncbi.nlm.nih.gov/pubmed/29401453

OneD: increasing reproducibility of Hi-C samples with abnormal karyotypes.

Vidal E, et. al.
Nucleic Acids Res.
https://www.ncbi.nlm.nih.gov/pubmed/29394371